Jittra Kornsakulkarna, Thapanee Pruksatrakula, Panida Surawatanawongb, Chattawat Thangsrikeattigunb, Somjit Komwijita, Nattawut Boonyuena, Chawanee Thongpanchanga,*

a National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road,
Klong Luang, Pathumthani, 12120, Thailand
bDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol
University, Bangkok, 10400, Thailand

Six new compounds 1–6 and two new naturally occurring compounds 7 and 8, together with nine known compounds 9–14, beauverioride I, dipicolinic acid, and 6-(methoxycarbonyl) picolinic acid were isolated from a wasp-pathogenic fungus Beauveria asiatica, strain BCC 16812. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compound 6 were established by the application of modified Mosher’s method
and ECD calculation. Compounds 9–11 exhibited antimalarial (IC50 0.47–1.79 u g/ mL), antimicrobial (MIC 3.13–50.0 u g/mL), and cytotoxic (IC50 0.26–1.23 u g/mL) activities, while compounds 1, 2, 8, and 14 showed only cytotoxicity against Vero cell lines, with IC50 values range 12.96–47.03 u g/mL.

Reference: Kornsakulkarn, J.; Pruksatrakul, T.; Surawatanawong, P.; Thangsrikeattigun, C.; Komwijit, S.; Boonyuen,
N.; Thongpanchang*, C. Phytochemistry Letters 2021, 43, 8-15. https://doi.org/10.1016/j.phytol.2021.03.003