Hathaichanok Sanjeam, Chutima Kuhakarn, Pawaret Leowanawat, Vichai Reutrakul, Darunee Soorukram*

We reported nitration of N-acetyl anilides using a simple combination of AgNO3/K2S2O8. The advantages of the present procedure include the practical operation in an open-flask, considerably mild reaction conditions, and acceptable reaction time (6 h) without additional catalyst. Scale-up synthesis could also be performed in this study. Although both para- and ortho-nitroanilides were formed, they could be readily separable by using a simple chromatographic technique. Additionally, the synthetic entry to both para- and ortho-nitroanilides, especially those possessing interesting chemical and biological activities, should be attractive where the structure-activity relationship (SAR) study are required.