Chiral resolution is an important process to separate a mixture of two enantiomers. In this work, tetrahydro-1,4-epoxynaphthalene-1-carboxylic acid (THENA), was used as a chiral resolving agent for binaphthol derivatives. The process is very efficient and could be used as a preliminary tool to assign the absolute configuration of substituted 1,1′-bi-2-naphthols by means of a simple TLC.


Dolsophon, K.; Ruangsupapichat, N.; Soponpong, J.; Sungsuwan, S.; Prabpai, S.; Kongsaeree, P.; Thongpanchang, T. Tetrahedron: Asymmetry 201627, 1113–1120.