Rachada Chanphen,a Thapanee Pruksatrakul,a Wilunda Choowong,a Rattaket Choeyklin,b Panida Surawatanawong,c Masahiko Isakaa,*

aNational Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand
bNational Biobank of Thailand, National Science and Technology Development Agency, 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani, 12120, Thailand
cDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand
       

Three previously undescribed highly modified lanostane triterpenoids, ganopyrone A, ganocolossusin I, and ganodermalactone Y, were isolated from the artificially cultivated fruiting bodies of the basidiomycete Gano derma colossus TBRC-BCC 17711. Ganopyrone A possesses an unprecedented polycyclic carbon skeleton with an α-pyrone ring and C-18/C-23 bond. It showed antimalarial activity against Plasmodium falciparum K1 (multidrug- resistant strain) with an IC 50 value of 7.8 μ M (positive control: dihydroartemisinin, IC 50 cytotoxicity (Vero cells) was much weaker (IC 50 103 μ M).

Reference: Chanphen, R.; Pruksatrakul, T.; Choowong, W.; Choeyklin, R.; Surawatanawong, P.; Isaka, M., Ganopyrone A, a highly rearranged lanostane triterpenoid with antimalarial activity from artificially cultivated fruiting bodies of Ganoderma colossus. Phytochemistry 2024, 224, 114168. https://doi.org/10.1016/j.phytochem.2024.114168