Trung Hieu Do, Supasorn Phaenok, Darunee Soorukram, Tina Modjinou, Daniel Grande, Thi Thanh Tam Nguyen,* and Thanh Binh Nguyen*

In this work, the new application of malonic acid and derivatives as a C1 synthon via double decarboxylation promoted by sulfur and dimethyl sulfoxide was reported. In the presence of amines as nucleophiles, a wide range of thioureas and thioamides as well as N-heterocycles were obtained in good to excellent yields under mild heating conditions.

Reference: Trung Hieu Do, Supasorn Phaenok, Darunee Soorukram, Tina Modjinou, Daniel Grande, Thi Thanh Tam Nguyen,* and Thanh Binh Nguyen* Synthesis of Thioureas, Thioamides, and Aza-Heterocycles via Dimethyl-Sulfoxide-Promoted Oxidative Condensation of Sulfur, Malonic Acids, and Amines. Org. Lett. 2023, 25, 6322.