Jittra Kornsakulkarna, Thapanee Pruksatrakula, Panida Surawatanawongb, Chattawat Thangsrikeattigunb, Somjit Komwijita, Nattawut Boonyuena, Chawanee Thongpanchanga,*

^a National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road,
Klong Luang, Pathumthani, 12120, Thailand
^bDepartment of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Mahidol
University, Bangkok, 10400, Thailand

Six new compounds 1–6 and two new naturally occurring compounds 7 and 8, together with nine known compounds 9–14, beauverioride I, dipicolinic acid, and 6-(methoxycarbonyl) picolinic acid were isolated from a wasp-pathogenic fungus Beauveria asiatica, strain BCC 16812. Their structures were determined by extensive spectroscopic analyses. The absolute configurations of compound 6 were established by the application of modified Mosher’s method
and ECD calculation. Compounds 9–11 exhibited antimalarial (IC50 0.47–1.79 u g/ mL), antimicrobial (MIC 3.13–50.0 u g/mL), and cytotoxic (IC50 0.26–1.23 u g/mL) activities, while compounds 1, 2, 8, and 14 showed only cytotoxicity against Vero cell lines, with IC50 values range 12.96–47.03 u g/mL.

Reference: Kornsakulkarn, J.; Pruksatrakul, T.; Surawatanawong, P.; Thangsrikeattigun, C.; Komwijit, S.; Boonyuen,
N.; Thongpanchang*, C. Phytochemistry Letters 2021, 43, 8-15. https://doi.org/10.1016/j.phytol.2021.03.003