This research is mainly collaborated with Dr. Boonlom Thavornyutikarn and Dr. Wanida Janvikul at National Metal and Materials Techology Center, and Associate Professor Dentist Weerachai
Singhatanadgit to develop material composites for drug delivery in the treatment of jaw bone infection. Here, Biodegradable composite hydrogels comprised of carboxymethyl chitosan (CMCS) and clindamycin (CDM)- loaded mesoporous silica nanoparticles (MCM-41), possessing dual antibacterial activity and osteogenic potency, were developed. CDM was successfully loaded into both untreated and plasma-treated MCM-41 nanoparticles, denoted as (p)-MCM-41, followed by the incorporation of each of CDM-loaded (p)-MCM-41 into CMCS. Novel (p)-MCM41-CDM-CMCS hydrogels with combined controlled release of CDM and osteogenic potency were successfully developed for the first time, suggesting their potential clinical benefit for treatment of intraoral bone infection.
1. Sungkhaphan P, Thavornyutikarn B, Kaewkong P, Pongkittiphan V, Pornsuwan S, Singhatanadgit W, Janvikul W, Antibacterial and osteogenic activities of clindamycinreleasing mesoporous silica/ carboxymethyl chitosan composite hydrogels, R. Soc. Open Sci. 2021; 8, 210808.