Natural rubber (NR) is a green elastomeric material obtained from the Hevea brasiliensis tree. The notable manners of NR, including high mechanical strength, excellent flexibility, ease of modification, and renewability, have been made it suitable for various end-use applications. Nevertheless, a large amount of isoprene unit along molecular chains provides NR with low thermal, oil, and ozone resistance. This work is aimed at improving these drawbacks through two chemical modification pathways using epoxidation followed by hydrogenation reaction in the latex system. The modified NRs (HENR) exhibited higher thermal and mechanical properties than the unmodified NR, including oil and ozone resistance. The modified NR vulcanizates still demonstrated the strain induced crystallization character as the NR.